WebJan 4, 2024 · The FDA has granted breakthrough therapy designation to CLN-081 for the treatment of patients with locally advanced or metastatic non–small cell lung cancer harboring EGFR exon 20 insertion ... WebJan 6, 2024 · CLN-081 received a breakthrough therapy designation from the FDA for patients with locally advanced or metastatic non–small cell lung cancer (NSCLC) with EGFR exon 20 mutations that has previously been treated with a systemic platinum-based chemotherapy regimen, according to a press release from developer Cullinan Oncology. 1
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WebJun 4, 2024 · These interim data of CLN-081 in this first-in-human trial show the results of dose escalation at 30, 45, 65, 100, and 150 mg twice daily. Doses of 30, 65, and 100 mg twice daily were initiated ... WebDescription. CLN1 disease is an inherited disorder that primarily affects the nervous system. Individuals with this condition have normal development in infancy, but typically by 18 months they become increasingly irritable and begin to lose previously acquired skills (developmental regression). In affected children, nerve cells in the brain ... linfocitos thf
CLN1 disease: MedlinePlus Genetics
WebDec 16, 2024 · CLN-081 is an orally available, irreversible EGFR inhibitor that selectively targets cells expressing EGFR exon 20 insertion mutations while sparing cells expressing wild type EGFR. Cullinan is evaluating various doses of CLN-081 in a Phase 1/2a trial in patients with NSCLC harboring exon 20 mutations whose disease has progressed on or … WebJun 4, 2024 · These interim data of CLN-081 in this first-in-human trial show the results of dose escalation at 30, 45, 65, 100, and 150 mg twice daily. Doses of 30, 65, and 100 mg twice daily were initiated for efficacy expansion. “ EGFR exon 20 insertions are the third most common subtype of EGFR mutations seen in NSCLC and have historically been ... WebJun 29, 2024 · CLN-619 is a first-in-class monoclonal antibody designed to promote an antitumor response by engaging both natural killer (NK) and T cells through the … hot tub pictures with deck