WebApr 1, 2015 · Collagenous micronodules (CMs) are microscopic stromal nodular eosinophilic fibrillar collagen deposition of uncertain histogenesis seen in prostatic adenocarcinoma. Per the 2005 International Society of Urologic Pathology (ISUP) consensus conference, they are categorized as Gleason pattern 3. This … WebSep 1, 2013 · The term “Collagenous spherulosis” (CS) was first introduced by Clement and colleagues in 1987 to describe a peculiar change of the breast.[] It is an uncommon benign change (occurs in less than 1-2% of all biopsies) and is an incidental microscopic finding involving lobular acini and ductules.
Collagenous spherulosis - Wikipedia
WebApr 25, 2024 · Collagenous spherulosis is a benign finding and does not require treatment. Adenoid cystic carcinoma is the main differential diagnosis which shows MYB-NFIB fusion gene, is negative for ER and … WebCollagenous spherulosis (CS) is an incidental finding that usually occurs in association with benign proliferative and preinvasive lesions. Adenomyoepithelioma is a biphasic … timothy franklin mylife az
Immunophenotypic overlap between adenoid cystic ... - Modern Pathology
WebJun 1, 2007 · Collagenous spherulosis and ACC both have a myoepithelial component that is responsible for the production of BM-like material. Hence, although the positive staining for smooth muscle actin (SMA) and p63 in this case highlighted the myoepithelial layer surrounding the cystic spaces (Fig. 2), it was not helpful in distinguishing between ... WebWeek 315: Case 4. June 25, 2007. Presented by George Netto, M.D. and prepared by Julie M. Wu, M.D. Case 4: A 45 year old woman with a suspicious density on mammographic exam. An open biopsy was obtained. Webconsisted of intraluminal clusters of eosinophilic spherules measuring approximately 20-100 µ in diameter. The spherules typically were found, and appeared to originate, within the spaces of fenestrated epitheliosis (“papillomatosis”). Special stains indicated that the spherules were collagen–rich, but also contained variable amounts of acidic mucin, … parousia rockstroh