WebCryptolepine was first shown as cytotoxic due to its reported interference with the nuclear ubiquitous enzyme topoisomerase II. 10 Topoisomerase II inhibition is a major mechanism of several anticancer agents including etoposide to induce apoptosis. 11 However, cells treated with cryptolepine in vitro have very low survival rates. 4 This report ... WebCryptolepis contains Indoquinoline alkaloids that exhibit strong anti-cancer properties. These alkaloids induce apoptosis and interfere with the cell cycle to prevent DNA biosynthesis. The major derivatives of indoquinoline alkaloids are neocryptolepine and cryptolepine, which are often extracted from the herb’s roots.
Stimulation of Topoisomerase II-Mediated DNA Cleavage by Three …
WebFeb 24, 1998 · Two syntheses of cryptolepine, including an unambiguous synthesis, are reported. The hydroiodide, hydrochloride, and hydrotrifluoromethanesulfonate (hydrotriflate) salts of cryptolepine were synthesized, and a comparison of their spectral properties and their in vitro activities in a 3T3-L1… View on PubMed doi.org Save to Library Create Alert Cite WebJan 1, 2024 · Cryptolepine content in roots of C. sanguinolenta in response to fertilizer treatments within four growth periods. The growth periods/plant ages are in months after transplanting (MAT), and CK, K, N, NPK, and P denote the treatments applied: Control, Potassium, Nitrogen, combined NPK, and Phosphorus, respectively. meaning of dragging
Synthetic cryptolepine inhibits DNA binding of NF-kappaB
WebCryptolepis sanguinolenta a plant that is used by traditional healers in Central and West Africa to treat infectious diseases, amoebiasis, and fever, including malaria [51,69]. … WebDec 1, 2024 · Guittat L, Alberti P, Rosu F, et al. Interaction of cryptolepine and neocryptolepine with unusual DNA structures. Biochem. 2003;85:535–541. doi ... Sathiyavimal S, Senthilkumar P, et al. Biosynthesis of iron oxide nanoparticles using leaf extract of Ruellia tuberose: antibacterial properties and their applications in photocatalytic … WebMay 4, 2024 · Cryptolepine inhibits melanoma cell growth through coordinated changes in mitochondrial biogenesis, dynamics and metabolic tumor suppressor AMPKα1/2-LKB1. Pal HC1, Prasad R1, Katiyar SK1 Author information Affiliations 3 authors 1. Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL, USA. ORCIDs linked … meaning of dragonflies