WebAug 19, 2015 · DNA origami is a robust assembly technique that folds a single-stranded DNA template into a target structure by annealing it with hundreds of short 'staple' … WebOct 28, 2024 · Three main features of this method simplify the determination of DNA origami folding behavior: 1) the sample can be used as is, i.e., no labeling or intercalating dye is needed; the latter may potentially influence DNA hybridization.
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WebMay 3, 2024 · A first principle–based, design-dependent model of DNA origami folding that can make quantitatively correct predictions would offer the possibility to rationalize design and production procedures, therefore moving the … WebAug 19, 2015 · DNA origami is a robust assembly technique that folds a single-stranded DNA template into a target structure by annealing it with hundreds of short ‘staple’ strands. Its guiding design principle is that the target structure is the single most stable configuration. The folding transition is cooperative and, as in the case of proteins, is ... gillian goodwin
Directing folding pathways for multi-component DNA origami ...
WebMay 6, 2016 · We exploit the ability to direct folding pathways to program the sequence of assembly and present a novel approach of designing the strand topology of intermediate folding states to program the topology of the final structure, in this case a DNA origami slider structure that functions much like a piston-cylinder assembly in an engine. WebDesign of the DNA origami structures Single-stranded M13mp18 DNA was used as the scaffold DNA of all the DNA origami structures used in this study. The designs of the triangular1 and hexagonal2 DNA origami structures (i.e., the staple sequences) have been described elsewhere; while the rectangular DNA origami was designed with the software ... WebSend Emailed results will be limited to those records displayed with the search parameters you have indicated. To export a larger list you will need to increase the number of results per page. gillian gilhooly caldwell