Witryna11 lip 2024 · Redox-responsive polymer-drug conjugate micelles are excellent nanoscale vehicles for self-immolative intracellular drug delivery. To covalently connect the … Witrynacells (Fig. 1a). A self-immolative para-aminobenzoyl carbamate (PABC) spacer is also required, to ensure the cathepsin-mediated cleavage is unimpeded by the payload. …
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WitrynaThere are provided herein, inter alia, complexes, compositions and methods for the delivery of therapeutic, diagnostic and imaging agents, including nucleic acid, into a … WitrynaSelf-immolative polymers, designed to release a chemical moiety, or a plurality of chemical moieties, upon a pre-determined cleavage event, or sequences of events, are disclosed. The polymers can be simple polymers, comb polymers or branched polymers. Further disclosed are methods of usage, compositions and articles-of-manufactures … how many persians died in thermopylae
A smart 19F and 1H MRI probe with self‐immolative linker as a …
WitrynaHere we report on a dual-modal 19 F and 1 H MRI paramagnetic probe with a self-immolative linker, Gd–DOMF–Gal. The enzymatic conversion of this probe by β … Witryna摘要:Self-immolative polymers, designed to release a chemical moiety, or a plurality of chemical moieties, upon a pre-determined cleavage event, or sequences of events, are disclosed. The polymers can be simple polymers, comb polymers or branched polymers. Further disclosed are methods of usage, compositions and articles-of-manufactures ... Witryna1 kwi 2024 · ADCs combining a novel self-immolative moiety and topoisomerase I inhibitor exatecan as payload show deep and durable response in low-target … how many perpetual heart for ayaka