Irs2 cancer

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August undefined, 2024

WebJun 15, 2024 · IRS2 is a cytoplasmic adaptor mediating effects of insulin and IGF-1 receptors and is involved in more aggressive behavior of different cancer types. In agreement with the genomic data, immunohistochemistry of human clinical samples showed increased expression of IRS2 protein in BM. WebNov 23, 2016 · IRS1 and IRS2 are the best studied members and are shown to have important roles in cell proliferation, survival, migration, metabolism and differentiation, and have been implicated in cancer...

IRS2 is a candidate driver oncogene on 13q34 in colorectal

WebApr 2, 2024 · These results indicate that Irs1 and Irs2 are required for Kras -driven lung tumor initiation and that Kras -transformed cells can eventually bypass Irs1 / Irs2 loss, developing more aggressive tumors at a highly variable and extended latency. Fig. 1. Loss of Irs1 and Irs2 significantly delays Kras -driven lung tumorigenesis. WebJan 9, 2024 · To investigate the clinical implications of IRS2 gain/amplification in cancer progression, we analyzed the SCLC dataset that is publicly available via the cBioPortal for Cancer Genomics (http://www.cbioportal.org/msk-impact). IRS2 amplification was … how much money will i save calculator

IRS2 - My Cancer Genome

WebApr 11, 2024 · The Arias-Stella reaction is a hormone-related atypical endometrial change characterized by cytomegaly, nuclear enlargement, and hyperchromasia of endometrial glands; typically associated with intrauterine or extrauterine pregnancies or with gestational trophoblastic disease. Although differentiating the Arias-Stella reaction (ASR) from clear … WebMar 29, 2024 · This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and … WebIn colorectal cancer, the up-regulation of DOK5 and IRS2 was associated with overall survival status, while in liver cancer, up-regulation was associated with increased vascular invasion. On the other hand, the up-regulation of different IGF/insulin signaling components can lead to similar clinical outcomes; in colorectal cancer, the up ... how do i shut down my gmail account

Systematic Survey of the Role of IGF in the Link Between Diabetes …

IJMS Free Full-Text In Silico Study to Predict the Structural and ...

WebThe IRS2 GD genotype reduced risk of colon cancer, except among those with an IRS1 R allele. No significant associations were seen in analyses of main effects or interactions of these variants and rectal cancer risk. Conclusions: Both IRS1 and IRS2 variants were associated with colon cancer risk independently. WebJul 15, 2013 · IRS2 is associated with cancer cell motility and metastasis. Currently, there are no anticancer agents that target IRS1/2. We present new IGF-IR/IRS-targeted agents (NT compounds) that promote inhibitory Ser-phosphorylation and degradation of IRS1 and IRS2. Elimination of IRS1/2 results in long-term inhibition of IRS1/2-mediated signaling. how do i shut down my ebay accountWebMar 4, 2024 · In addition, it was found that IRS2 silencing had an inhibitory effect on the progression of NSCLC, and the upregulation of IRS2 partially impaired the inhibitory effect of miR‐448 in NSCLC. how do i shut down my hp laptop correctly

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Irs2 cancer

WebSynonyms [ 1] IRS-2. Insulin receptor substrate 2 (IRS2) is a gene that encodes a protein of the same name that functions in regulating the effects of insulin-like growth factor 1 and insulin by mediating signaling between receptor tyrosine kinases and other associated … WebJun 15, 2024 · IRS2 is a cytoplasmic adaptor mediating effects of insulin and IGF-1 receptors and is involved in more aggressive behavior of different cancer types. In agreement with the genomic data, immunohistochemistry of human clinical samples …

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WebAug 8, 2024 · The insulin-like growth factor-1 (IGF-1) signaling pathway has been implicated in non-small cell lung cancer (NSCLC) outcomes and resistance to targeted therapies. However, little is known regarding the molecular mechanisms by which this pathway contributes to the biology of NSCLC. The insulin receptor substrate (IRS) proteins are … WebMechanistically, insulin receptor substrate 2 (IRS2) was identified as a direct target of miR‑766 in PTC cells. IRS2 was upregulated in PTC tissues, and this was inversely correlated with miR‑766 expression. Inhibition of IRS2 simulated the tumor suppressor activity of …

http://www.cancerindex.org/geneweb/IRS2.htm WebThe IR of any CVC-related complication was numerically higher in patients with SBS with cancer vs without cancer (3.44 vs 1.86 cases per 1,000 catheter-days, respectively). Conclusion: Our study quantifies the incidence of complications in patients with CVCs, including those with SBS, in Japan. Keywords: database, epidemiology, prevalence ...

WebApr 19, 2024 · The identification of somatic mutations in IRS2 in 29% of PILC samples is the first report of recurrent IRS2 mutation in any subtype of breast cancer to our knowledge. IRS2 is an adaptor protein for the insulin and IGF-1 receptors, and it mediates their … WebApr 9, 2024 · Insulin receptor substrate 2 (IRS2) belongs to the member of IRS family that regulates cell proliferation, apoptosis, and metabolism by functioning as a molecular adaptor to integrate and coordinate extracellular signals from insulin and other ligands to mitochondria (Dearth et al. 2007 ).

WebMar 18, 2024 · Breast cancers that do not express the estrogen receptor (ER) or the progesterone receptor (PR) and have no ERBB2 (commonly referred to as human epidermal growth factor receptor 2 [HER2]) amplification are categorized as triple-negative breast cancers (TNBCs) and comprise 10%–20% of all breast cancers ( Dent et al., 2007, …

WebJan 9, 2024 · Small cell lung cancer (SCLC) is a fast-growing and malignant cancer that responds well to chemotherapy; however, the survival rate is less than 15% after 2 years of diagnosis. Therefore, novel therapeutic agents for treating SCLC patients need to be evaluated. This study aims to identify the therapeutic targets based on the comprehensive … how much money will last a lifetimeWebDec 3, 2015 · 2 Knight Cancer Institute, Division of Hematology and Medical Oncology, Oregon Health & Science ... harbored a mutation in the insulin receptor substrate 2 (IRS2) gene. IRS2 belongs to the IRS family of cytoplasmic adaptor proteins that function as essential signaling intermediates for intracellular signaling pathways to modulate normal … how do i shut down my lenovo yoga 7i laptopWebMay 1, 2016 · In the last years, many studies have indicated that IRS2 participates in the regulation of important biological processes involved in cancer phenotype, including cell proliferation, clonogenicity, metabolism and survival. The present review contains data on … how much money will minecraft legends costWebJan 24, 2024 · Recent data indicate that IGF1R/IRS signaling is a potential therapeutic target in BCR-ABL1-negative myeloproliferative neoplasms (MPN); in this pathway, IRS2 is involved in the malignant ... how much money will overwatch 2 beWebJul 7, 2013 · IRS2 is associated with cancer cell motility and metastasis. Currently there are no anti-cancer agents that target IRS1/2. We present new IGF1R/IRS-targeted agents (NT compounds) that promote inhibitory Ser-phosphorylation and degradation of IRS1 and IRS2. how do i shut down my laptopWebIRS2 INFORMATION. Proteini. Full gene name according to HGNC. Insulin receptor substrate 2. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to HGNC. IRS2. Protein classi. Assigned … how do i shut down my computerdownWebMay 1, 2016 · Jackson and colleagues (Jackson, et al. 1998) observed that IRS2 is widely expressed in breast cancer cell lines and primary breast cancer cells. In breast cancer patients, membrane localization of IRS-2 was associated with reduced overall survival by multivariate analysis (Clark, et al. 2011). how do i shut down my venmo account