Toxicities of 166holmium-chitosan in mice

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August undefined, 2024

WebApr 13, 2024 · The chitosan-coated nanoemulsions with TMZ showed the expected physicochemical characteristics and demonstrated safety and efficacy, reducing around 70% the tumor size compared to control mice, and presenting a tendency in mitotic index reduction, becoming an interesting approach to treat melanoma brain metastasis. ... To … WebFeb 5, 2024 · The term mushroom refers to the fungal fruiting body. Anatomically, the prototypical mushroom comprises the stem and a cap with gills on the underside. However, the term may refer to many …

Assessment of in vivo chronic toxicity of chitosan and its …

WebApr 8, 2024 · The use of silver nanoparticles (AgNPs) embedded in polymeric matrix has acquired special attention as a strategy to reduce metal toxicity without losing its antimicrobial effect. In this work, the green synthesis of AgNPs and their functionalization with chitosan (AgNPs@Chi) was performed, and their antifungal activity investigated … WebJan 1, 2024 · In an acute toxicity test, mice (n = 20, 10 male, 10 female) were administered a single dose of 10 g/kg BW of Lithothamnion sp. No mortality, or signs of toxicity were … senior homes kingston ontario

Toxicology/Carcinogenicity - National Toxicology Program

WebDec 1, 2024 · Fecal moisture was significantly increased in 9% males (up to 170%) and 9% females at all time points, in 3% males during week 6, and … WebSep 20, 2024 · This study assessed the protective effects of selenium-chitosan (SC) against antioxidant and immune function-related damage induced by zearalenone (ZEN) in mice. In total, 150 female mice were allotted to five groups for a 30-day study. Control mice were fed a basal diet. Mice in the ZEN, ZEN-Se1, ZEN-Se2 and ZEN-Se3 groups were fed the basal … WebResults: After administration of 166Ho-chitosan complex, the radioactive concentrations in blood were low, and cumulative urinary and fecal excretions over a period of 0-72 hr were … senior horizons at newburgh

Phase II study of transarterial holmium-166-chitosan complex treatment …

Evaluation of acute and sub-chronic toxicity of lithothamnion sp.

WebNov 7, 2024 · As in the rodent model, Huh et al. have reported that 166 Ho chitosan complex can be used for the treatment of malignant glioma in mice model when injected at the … WebTo investigate the single dose toxicity, mice were administered intravenously with 1 mCi/kg body weight of 166Ho-Chit (DW-166HC), Chit or nothing. Organ weights, hematological … senior homes rich baby boomersWebGeneral toxicology screens are typically carried out as contracted studies at several commercial laboratories in the U.S. These short-term studies usually expose rats and mice of both sexes to a substance for a period of either 14 days or 13 weeks. Typical assessments performed may include: Clinical pathology Estrous cycle length Sperm motility senior horizons middletown ny

"Web166 Holmium-Chitosan complex, in which chitosan is chelated with 166 Holmium, was developed as a radiopharmaceutical for cancer therapy. We have conducted a pilot study to evaluate the clinical efficacy of transarterial administration of 166 Holmium-Chitosan complex in patients with a single and small (< 3 cm) hepatocellular carcinoma. 166 " - Toxicities of 166holmium-chitosan in mice

Toxicities of 166holmium-chitosan in mice

Toxicology/Carcinogenicity - National Toxicology Program

WebMay 11, 2024 · Disc diffusion method was used to test for activity against Escherichia coli ( E. coli) and Staphylococcus aureus ( S. aureus) with Fosbac as the positive control. Acute toxicity in mice through oral administration of the nanoparticles solution at … WebDec 1, 2005 · The fate of 166Ho-chitosan complex, a radiopharmaceutical drug for cancer therapy, was determined by studying its absorption, distribution and excretion in rats and …

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WebMar 1, 1998 · In this study, 166Ho was complexed to chitosan (Chit) which decreases the distribution of Ho into other tissues when applied intrahepatically. To investigate the … WebMar 9, 2024 · In vivo toxicity evaluation of tumor targeted glycol chitosan nanoparticles in healthy mice: repeated high-dose of glycol chitosan nanoparticles potentially induce cardiotoxicity This study demonstrates that repeated high-dose CNPs induce severe cardiotoxicity in vivo.

WebAn immunization protocol was designed in mice to investigate anti-toxin immunity and the protective status induced by different Aah II immune formulations. Unloaded chitosan nanoparticles presenting a spherical shape and smooth surface, were characterized by a size of 185 nm, a dispersion index (PDI) of 0.257 and a zeta potential of +34.6 mV. WebNov 21, 2014 · Although chitosan is reported to be non-toxic, the in vivo toxicity assay demonstrated that the LD50 of chitosan is 16 g kg −1 in mice. Assessment of the toxicity …

WebApr 13, 2024 · The most successful medical intervention for preventing infectious diseases is still vaccination. This effective strategy has resulted in decreased mortality and extended life expectancy. However, there is still a critical need for novel vaccination strategies and vaccines. Antigen cargo delivery by nanoparticle-based carriers could promote superior … WebApr 1, 2024 · To evaluate the biological safety of chitosan nanoparticles, chronic toxicity study was conducted in Swiss albino mice. Briefly, the animals were divided into two groups of 5 each. Animals of group I were given corn oil in normal diet on alternative days and those of group II were fed with 0.5% dosage of void nanoparticles in water on ...

WebLee, W.Y. et al. Toxicities of 166Holmium-chitosan in mice. Arzneimittelforschung 48 , 300–304 ( 1998). CAS PubMed Google Scholar

WebDec 10, 2024 · This study was conducted to evaluate the subacute toxicity effect of Chitosan-alginate coated microparticle of Garcinia mangostana Linn extract’s oral administration. Fifty BALB/c mice were... senior homes on peiWebJun 8, 2024 · In vivo toxicities of TP and CCTP were compared by using normal BALB/c mice that were evaluated by monitoring body weight change and hematological toxicity . Previous experiments showed that the minimum lethal dose of mice was about 0.5 mg TP/kg. Here, a safe dose of free TP of 0.2 mg/kg was adopted for mice in toxicity assay. senior horizons at clifton njWebSep 20, 2024 · This study assessed the protective effects of selenium-chitosan (SC) against antioxidant and immune function-related damage induced by zearalenone (ZEN) in mice. … senior homes rent chennaiWebMar 1, 1998 · In this study, 166Ho was complexed to chitosan (Chit) which decreases the distribution of Ho into other tissues when applied intrahepatically. To investigate the single dose toxicity, mice were administered intravenously with 1 mCi/kg body weight of 166Ho … senior homes spruce groveWebChitosan oligomers did not induce morphologic sperm abnormalities in male mice following oral gavage daily for 5 days with up to 5,000 mg/kg. 21. … senior horse nutritionWebChitosan is a cationic carbohydrate polymer that is commercially derived from the deacetylation of chitin obtained from seafood shells. The most widespread route of human exposure to chitosan is as a dietary … senior homes shawnee ksWebNov 17, 2008 · Europe PMC is an archive of life sciences journal literature. senior horse weight gain supplement